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脑卒中的康复治疗
刁建生;沈敏杰
现代康复 1999年 3卷2期 页码:204-205页,共2页
无关键词信息
脑卒中(脑血管疾病)是指发展迅速具有血管源性的局限性脑功能障碍,且症状持续24h以上或导致死亡的临床症候群,在我国是常见病多发病.其特点为后遗症多、致残率高、复发性大,残疾主要是偏瘫(肢体运动功能障碍).应用综合的康复医疗技术治疗卒中后偏瘫,能在很大程度上提高或改善其肢体运动功能而减轻残疾.但病后的康复治疗是一个较长的过程,还存在着很多影响因素:病人入院的标准不一致,疾病的类型,治疗期限,康复开始的时间差别等.若无完善的康复治疗措施,便不能达到预期的效果.卒中后的康复是指病侧神经系统重新获得对病侧的控制,这是卒中康复的重要内容.用传统的方法与神经生理学方法通过感觉输入促进或抑制中枢神经系统的活动,应用神经发育学概念促进神经肌肉的反应,通过全身各关节的运动强调其协调性并反复学习与强化.早期积极预防关节挛缩、畸型,用PROM(关节全范围被动体操)保持关节活动度,尽早进行从床到椅到站立的活动,训练和强化健侧功能以代偿患侧,可收到较好的治疗效果.在出现随意运动后不引起异常运动反应的情况下,进行加强肌力、耐力和协调张力训练.本文就近年来国内外有关资料,结合临床经验将影响脑卒中康复的因素和康复治疗措施,介绍如下.
Curative effects on muscle function and proprioception in patients with chronic lumbar disk herniation using isokinetic trunk muscle strength training
Zhang, XH; Bi, X; Shao, JW; Sun, D; Zhang, C; Liu, ZH
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 2019年 12卷4期 页码:4311-4320
LOW-BACK-PAIN; STABILITY; EXERCISE; PATTERNS
The aim of this study was to evaluate the curative effects on muscle function and proprioception in patients with chronic lumbar disk herniation (LDH) using two kinds of kinesitherapies: isokinetic trunk muscle strength training and core muscle training. Eighty patients with clinical features of lumbar disk herniation were randomly divided into treatment and control groups (40 patients in each group). All participants were given routine rehabilitation treatment, including interferential electrotherapy, microwave therapy, lumbar traction treatment, and other physical therapies. The treatment group received isokinetic trunk muscle strength training, while the control group received core muscle training, both lasting for 8 weeks, three times per week. Improvement in patient motor and sensory function, before and after treatment, was evaluated using lower back pain standard scoring criteria of Japanese Orthopedic Association (JOA), Oswestry disability index (ODI), and visual analogue scale (VAS). After 8 weeks of continuous training, trunk muscle strength evaluation indexes of the patients in the two groups significantly increased, compared to before treatment. Moreover, JOA, ODI and VAS scores suggested that both treatments could significantly improve lumbar function concerning trunk muscle strength, rehabilitation evaluation of lumbar function, and lumbar proprioception assessment. Furthermore, the ontology sense test indicated that the absolute error value of proprioception was reduced after both routine rehabilitation treatment and isokinetic trunk muscle strength training treatment. In conclusion, this study showed that isokinetic trunk muscle strength training could improve proprioception in patients with chronic lumbar disk herniation. It also enhanced muscle function, compared with core muscle training.
Association of Self-Leadership With Acute Stress Responses and Acute Stress Disorders in Chinese Medics During the COVID-19 Pandemic: A Cross-Sectional Study
Ji, RJ; Zhang, L; Ji, YB; Li, GZ; Wang, RX; Xu, CP
FRONTIERS IN PSYCHIATRY 2022年 13卷 页码:-null
无关键词信息
BackgroundThe outbreak of the highly infectious coronavirus disease 2019 (COVID-19) renders a huge physical and psychological risk to the public, especially to the medics. Additionally, self-leadership has proven to improve self-efficacy and mediate tension, such as nervousness and depression. Therefore, a cross-sectional survey was conducted to explore the association of self-leadership with acute stress responses (ASRs) and acute stress disorders (ASDs) in medics during the COVID-19 epidemic. MethodsSelf-reported online questionnaires were administered, and 627 participants were finally included. The data were analyzed using the univariate analysis and the logistical regression model to identify whether self-leadership and sociodemographic and epidemic characteristics were associated with mental health, including ASRs and ASDs. ResultsInitially, 790 medics responded. Of these, 627 remained after excluding for invalid questionnaires and those with a substantial amount of missing data. Therefore, the participation validity rate was 79.37%. Frontline medical staff (beta = 0.338; p < 0.001), possibility of infection among people around the medic being mild (beta = 0.141; p < 0.001), subjective estimation of epidemic duration being 3-6 months (beta = 0.074; p < 0.05), self-sets (beta = -0.022; p < 0.001), self-punishment (beta = 0.229; p < 0.001), belief hypothesis and evaluation (beta = -0.147; p < 0.05), and successful foresight (beta = 0.105; p < 0.05) were statistically significant with ASRs. Marital status [adjusted odds ratio (AOR) =1.813; 95% CI (1.141, 2.881); p = 0.012], being a frontline worker [AOR = 25.760; 95% CI (14.220, 46.667); p < 0.001], visiting Hubei in the previous 14 days [AOR = 3.656; 95% CI (1.500, 8.911); p = 0.004], self-punishment [AOR = 1.352; 95% CI (1.180, 1.548); p < 0.001], and self-dialogue [AOR = 1.256; 95% CI (11.063, 1.483); p = 0.007] were the risk factors for ASD. Conversely, having frontline medical staff in one's family [AOR = 0.523; 95% CI (0.297, 0.923); p = 0.025], self-sets [AOR = 0.814; 95% CI (0.715, 0.826); p = 0.002], and belief hypothesis and evaluation [AOR = 0.796; 95% CI (0.672, 0.943); p = 0.038] were the protective factors. ConclusionThe special working environment of the COVID-19 epidemic resulted in ASR and ASD. Notably, findings revealed a positive association between ASR symptoms and frontline medical staff, the subjective estimation of epidemic duration, self-punishment, and successful foresight. Nevertheless, marital status, having visited Hubei in the previous 14 days, and self-dialogue were the risk factors accounting for ASD symptoms. Surprisingly, having frontline medical staff in one's family, self-sets, and belief hypothesis and evaluation had potential benefits for ASD symptoms.
MicroRNA-22-3p ameliorates Alzheimer's disease by targeting SOX9 through the NF-kappa B signaling pathway in the hippocampus
Xia, PC; Chen, J; Liu, YC; Cui, XL; Wang, CC; Zong, S; Wang, L; Lu, ZM
JOURNAL OF NEUROINFLAMMATION 2022年 19卷1期 页码:-null
无关键词信息
Background: Studies have suggested that many down-regulated miRNAs identified in the brain tissue or serum of Alzheimer's disease (AD) patients were involved in the formation of senile plaques and neurofibrillary tangles. Specifically, our previous study revealed that microRNA-22-3p (miR-22-3p) was significantly down-regulated in AD patients. However, the molecular mechanism underlying the down-regulation of miR-22-3p has not been comprehensively investigated. Methods: The ameliorating effect of miR-22-3p on apoptosis of the A beta-treated HT22 cells was detected by TUNEL staining, flow cytometry, and western blotting. The cognition of mice with stereotaxic injection of agomir or antagomir of miR-22-3p was assessed by Morris water maze test. Pathological changes in the mouse hippocampus were analyzed using hematoxylin and eosin (HE) staining, Nissl staining, and immunohistochemistry. Proteomics analysis was performed to identify the targets of miR-22-3p, which were further validated using dual-luciferase reporter analysis and western blotting analysis. Results: The miR-22-3p played an important role in ameliorating apoptosis in the A beta-treated HT22 cells. Increased levels of miR-22-3p in the mouse hippocampus improved the cognition in mice. Although the miR-22-3p did not cause the decrease of neuronal loss in the hippocampus, it reduced the A beta deposition. Proteomics analysis revealed Sox9 protein as the target of miR-22-3p, which was verified by the luciferase reporter experiments. Conclusion: Our study showed that miR-22-3p could improve apoptosis and reduce A beta deposition by acting on Sox9 through the NF-kappa B signaling pathway to improve the cognition in AD mice. We concluded that miR-22-3p ameliorated AD by targeting Sox9 through the NF-kappa B signaling pathway in the hippocampus.
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