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Seven-year Follow-up of LASIK for Moderate to Severe Myopia
Liu, ZQ;Li, Y;Cheng, ZY;Zhou, F;Jiang, H;Li, JH
JOURNAL OF REFRACTIVE SURGERY 2008年 24卷9期 页码:935-940
IN-SITU KERATOMILEUSIS; ONE-YEAR OUTCOMES; PHOTOREFRACTIVE KERATECTOMY; REFRACTIVE CHANGES; LASER; EYE; SURGERY
PURPOSE: To evaluate long-term refractive outcomes of LASIK for correcting moderate to severe myopia.;-;METHODS: A long-term (7-year) prospective follow-up study of visual and refractive outcomes in patients who underwent myopic LASIK surgery in 1998 and 1999. Fifty-nine patients (104 eyes) of the original cohort of 75 patients underwent detailed clinical assessment at 1 and 7 years postoperatively. The main outcome measures were predictability, efficacy, safety, and stability. Topography, corneal thickness, and postoperative complications were recorded at 7 years. All patients completed a questionnaire assessing their satisfaction with the procedure.;-;RESULTS: At 7 years postoperatively, 89.4% of eyes were within 0.50 diopters (D) of attempted correction, and 90.4% were within 1.00 D. All eyes had 20/40 or better vision and 94.2% had 20/20 or better. Best spectacle-corrected visual acuity was unchanged or improved in 80.8% of eyes. Eyes did not regress in refraction between 1 and 7 years postoperatively. Complications were rare and patient satisfaction with the surgery was high.;-;CONCLUSIONS: LASIK surgery has predictable and stable results in refractive and visual outcomes in correcting moderate to high myopia on long-term follow-up. Refractive stability is maintained over 7 years, with no evidence of progressive late-onset complications. [J Refract Surg. 2008;24:935-940.]
Prevalence and Risk Factors for Pterygium in Rural Older Adults in Shandong Province of China: A Cross-Sectional Study
Jiao, WZ;Zhou, CC;Wang, T;Yang, SY;Bi, HS;Liu, LP;Li, Y;Wang, LH
BIOMED RESEARCH INTERNATIONAL 2014年
POPULATION; EYE; EPIDEMIOLOGY; RECURRENCE; SINGAPORE; SEVERITY; HEALTH
To investigate the prevalence and risk factors for pterygium in rural older adults in Shandong Province, eastern China, a population-based, cross-sectional study was performed from April to July 2008. By means of cluster random sampling methods, a total of 19,583 people aged 50 years or above were randomly selected from four rural counties. Out of 19,583 people, 1,767 residents were excluded mainly because they were migrant workers when this study was performed. Finally, 17,816 (90.98%) people were included as eligible subjects. They received a comprehensive eye examination and a structured questionnaire voluntarily. Patients with pterygium were defined as having pterygium at the time of survey or pterygium surgery had been performed. 1,876 people were diagnosed as pterygium, either unilateral (1,083) or bilateral (793), which is equivalent to a prevalence of 10.53% (95% CI, 10.08-10.98). The multivariate logistic regression analysis showed that pterygium was independently associated with older age, areas, outdoor time, educational level, and use of hat and/or sunglasses. The prevalence of pterygium increased with age and hours spent under sunshine per day. Meanwhile, the higher the educational level and the more use of hat and/or sunglasses, the lower the pterygium prevalence.
Meta-analysis of association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma 2 gene and diabetic retinopathy in Caucasians and Asians
Ma, JL;Li, Y;Zhou, F;Xu, XY;Guo, G;Qu, Y
MOLECULAR VISION 2012年 18卷248期 页码:2352-2360
PPAR-GAMMA GENE; IMPROVED INSULIN SENSITIVITY; BODY-MASS INDEX; DECREASED RISK; PPAR-GAMMA-2 GENE; MISSENSE MUTATION; MELLITUS; VARIANT; IDENTIFICATION; SUBSTITUTION
Purpose: The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma 2 (PPAR gamma 2) gene is reported to be associated with diabetes. However, the gene's association with diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) has been investigated in numerous epidemiologic studies with controversial results. This meta-analysis aimed to collectively assess the association of the Pro12Ala polymorphism with DR in T2DM.;-;Methods: An electronic literature search was conducted on PubMed, ISI Web of Knowledge, EMBASE, and the China National Knowledge Internet. A dominant model [(Pro/Ala + Ala/Ala) versus Pro/Pro] was used to ensure adequate statistical power. Crude odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using the fixed effect model. Potential sources of heterogeneity and bias were explored.;-;Results: This meta-analysis included genotype data from 2,720 cases with DR and 2,450 controls free of DR from eight eligible publications. The results showed the Ala allele had a protective effect on DR in T2DM (OR=0.81; 95% CI: 0.68-0.98, p=0.03). There was no significant evidence against homogeneity (I-2=46%, P-heterogeneity=0.07). The sensitivity analysis showed a robust association of the Pro12Ala polymorphism with DR in T2DM after a study involving Caucasians that presented a big effect on heterogeneity (OR=0.75; 95% CI: 0.62-0.91, p=0.003) was excluded. Possible ethnic differences in the association of the Pro12Ala single nucleotide polymorphism and DR were demonstrated; a significant association was illustrated in the Caucasian subgroup (OR=0.74; 95% CI: 0.59-0.94, p=0.01) but was not found in the Asian subgroup (OR=0.77; 95% CI: 0.55-1.07, p=0.12). No publication bias was observed.;-;Conclusions: This meta-analysis suggested a significant association exists between the Pro12Ala polymorphism and DR in T2DM with ethnic differences. The Ala allele had a significant protective effect against DR in T2DM.
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