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重症监护病房新生儿听力筛查未通过的危险因素分析
王春芹;任香娣;吴长珍
山东医药 2015年 55卷17期 页码:42-44页,共3页 影响因子:0.805
新生儿;听力筛查;危险因素
目的 分析重症监护病房新生儿听力筛查未能通过的危险因素. 方法 回顾性调查1 670例新生儿听力筛查情况. 通过多因素Logistic回归分析,筛选出新生儿听力筛查未通过的危险因素. 结果 未通过听力筛查的新生儿345例(20.7%). 单因素分析结果显示,胎龄≤32周、出生体质量≤1 500 g、颅面部畸形、巨细胞病毒引起的宫内感染、达到换血标准的高胆红素血症、胆红素脑病、新生儿神经行为测定( NBNA)评分≤35分与新生儿听力筛查未通过有相关性(P均<0.05). 多因素Logistic回归分析结果显示,出生体质量≤1 500 g、颅面部畸形、胆红素脑病、NBNA评分≤35分是听力筛查未通过的独立危险因素. 结论 重症监护病房新生儿听力筛查不能通过的危险因素有出生体质量≤1 500 g、颅面部畸形、胆红素脑病、NBNA评分≤35分.
Measuring Spectral Inconsistency of Multispectral Images for Detection and Segmentation of Retinal Degenerative Changes
Lian, J;Zheng, YJ;Duan, PY;Jiao, WZ;Zhao, BJ;Ren, YJ;Shen, DG
SCIENTIFIC REPORTS 2017年 7卷
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Multispectral imaging (MSI) creates a series of en-face fundus spectral sections by leveraging an extensive range of discrete monochromatic light sources and allows for an examination of the retina's early morphologic changes that are not generally visible with traditional fundus imaging modalities. An Ophthalmologist's interpretation of MSI images is commonly conducted by qualitatively analyzing the spectral consistency between degenerated areas and normal ones, which characterizes the image variation across different spectra. Unfortunately, an ophthalmologist's interpretation is practically difficult considering the fact that human perception is limited to the RGB color space, while an MSI sequence contains typically more than ten spectra. In this paper, we propose a method for measuring the spectral inconsistency of MSI images without supervision, which yields quantitative information indicating the pathological property of the tissue. Specifically, we define mathematically the spectral consistency as an existence of a pixel-specific latent feature vector and a spectrum-specific projection matrix, which can be used to reconstruct the representative features of pixels. The spectral inconsistency is then measured using the number of latent feature vectors required to reconstruct the representative features in practice. Experimental results from 54 MSI sequences show that our spectral inconsistency measurement is potentially invaluable for MSI-based ocular disease diagnosis.
Joint alignment of multispectral images via semidefinite programming
Zheng, YJ;Wang, Y;Jiao, WZ;Hou, SJ;Ren, YJ;Qin, ML;Hou, DW;Luo, C;Wang, H;Gee, J;Zhao, BJ
BIOMEDICAL OPTICS EXPRESS 2017年 8卷2期 页码:890-901
REGISTRATION; SEGMENTATION; MODELS
In this paper, we introduce a novel feature-point-matching based framework for achieving an optimized joint-alignment of sequential images from multispectral imaging (MSI). It solves a low-rank and semidefinite matrix that stores all pairwise-image feature-mappings by minimizing the total amount of point-to-point matching cost via a convex optimization of a semidefinite programming formulation. This unique strategy takes a complete consideration of the information aggregated by all point-matching costs and enables the entire set of pairwise-image feature-mappings to be solved simultaneously and near-optimally. Our framework is capable of running in an automatic or interactive fashion, offering an effective tool for eliminating spatial misalignments introduced into sequential MSI images during the imaging process. Our experimental results obtained from a database of 28 sequences of MSI images of human eye demonstrate the superior performances of our approach to the state-of-the-art techniques. Our framework is potentially invaluable in a large variety of practical applications of MSI images. (C) 2017 Optical Society of America
Comparison of Conbercept with Ranibizumab for the Treatment of Macular Edema Secondary to Branch Retinal Vein Occlusion
Li, FJ;Sun, M;Guo, JL;Ma, AH;Zhao, BJ
CURRENT EYE RESEARCH 2017年 42卷8期 页码:1174-1178
ENDOTHELIAL GROWTH-FACTOR; EFFICACY
Purpose: To confirm the therapeutic efficacy of conbercept for the treatment of macular edema (ME) secondary to branch retinal vein occlusion (BRVO).Methods: In this prospective, randomized, and comparative study, patients were randomized and divided into conbercept (n = 18) and ranibizumab (n = 17) groups. After an initial intravitreal injection of either conbercept or ranibizumab, a pro re nata (PRN) strategy was adopted based on loss of visual acuity (VA) or increase in central macular thickness (CMT).Results: All patients were followed for 6 months. Baseline best-corrected visual acuities (BCVAs) were 0.67 0.37 and 0.511 +/- 0.23 logMAR in the conbercept and ranibizumab groups, respectively (p = 0.087, t-test). Baseline CMTs were 512.5 +/- 115.22 and 491.23 +/- 114.72 mu m in the conbercept and ranibizumab groups, respectively (p = 0.993, t-test). Significant improvements in BCVA and reduction of CMT were observed in both groups at each follow-up visit and compared to baseline values (p < 0.05, t-test). No significant differences in improvement of BCVA (p > 0.05, t-test) or reduction of CMT (p > 0.05, t-test) were noted in either group. Mean numbers of injections were 2.28 +/- 0.96 and 2.65 +/- 1.17 for the conbercept and ranibizumab groups, respectively (p = 0.478, t-test), with no statistically significant differences between the two groups.Conclusion: Intravitreal injection of conbercept is shown to be safe and effective for the treatment of ME secondary to BRVO, based on 6-month follow-up data.
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