在结果中搜索
成果类型 (Type)
收录类型 (Indexed By)
语言 (Language)
- 已选条件:
Association of complement components with the risk and severity of NAFLD: A systematic review and meta-analysis
Zhao, JB; Wu, YF; Lu, P; Wu, XQ; Han, JM; Shi, YZ; Liu, Y; Cheng, YP; Gao, L; Zhao, JJ; Wang, Z; Fan, XD
FRONTIERS IN IMMUNOLOGY 2022年 13卷
无关键词信息
Background: It is generally believed that complement system is strongly associated with the risk of nonalcoholic fatty liver disease (NAFLD). However, complement system contains a variety of complement components, and the relationship between complement components and the risk and severity of NAFLD is inconsistent. The aim of this meta-analysis was to evaluate the association of complement components with the risk and severity of NAFLD.Methods: We searched PubMed, Embase, Cochrane Library, Google Scholar, Scopus, and ZhiWang Chinese databases from inception to May 2022 for observational studies reporting the risk of NAFLD with complement components. Random-effects meta-analysis was used to obtain pooled estimates of the effect due to heterogeneity.Results: We identified 18 studies with a total of 18560 included subjects. According to recent studies, levels of complement component 3 (C3) (mean difference (MD): 0.43, 95% confidence interval (CI) 0.26-0.60), complement component 4 (C4) (MD: 0.04, 95% CI 0.02-0.07), complement component 5(C5) (MD: 34.03, 95% CI 30.80-37.27), complement factor B (CFB) (MD: 0.22, 95% CI 0.13-0.31) and acylation stimulating protein (ASP) (standard mean difference (SMD): 5.17, 95% CI 2.57-7.77) in patients with NAFLD were significantly higher than those in the control group. However, no statistical significance was obtained in complement factor D (CFD) levels between NAFLD and non-NAFLD (MD=156.51, 95% CI -59.38-372.40). Moreover, the levels of C3, C5, CFB, and ASP in patients with moderate and severe NAFLD were significantly higher than those in patients with mild NAFLD. Except for C4 and CFD, the included studies did not explore the changes in the severity of NAFLD according to the concentration of C4 and CFD.Conclusions: This meta-analysis demonstrates that an increase in complement components including C3, C5, CFB, and ASP is associated with an increased risk and severity of NAFLD, indicating that they may be good biomarkers and targets for the diagnosis and treatment of NAFLD.
Prime Editing in Mammals: The Next Generation of Precision Genome Editing
Wang, DW; Fan, XD; Li, MZ; Liu, TB; Lu, P; Wang, GX; Li, Y; Han, JM; Zhao, JJ
CRISPR JOURNAL 2022年 5卷6期 页码:746-
无关键词信息
The recently established prime editor (PE) system is regarded as next-generation gene-editing technology. This methodology can install any base-to-base change as well as insertions and deletions without the requirement for double-stranded break formation or donor DNA templates; thus, it offers more targeting flexibility and greater editing precision than conventional CRISPR-Cas systems or base editors. In this study, we introduce the basic principles of PE and then review its most recent progress in terms of editing versatility, specificity, and efficiency in mammals. Next, we summarize key considerations regarding the selection of PE variants, prime editing guide RNA (pegRNA) design rules, and the efficiency and accuracy evaluation of PE. Finally, we highlight and discuss how PE can assist in a wide range of biological studies and how it can be applied to make precise genomic corrections in animal models, which paves the way for curing human diseases.
Ctnnb1/beta-catenin inactivation in UCP1-positive adipocytes augments the browning of white adipose tissue
Chen, N; Yuan, MY; Zhang, NN; Chen, MP; Liu, RX; Wang, JQ; Lu, P
ISCIENCE 2023年 26卷5期 页码:-null
无关键词信息
Canonical WNT pathway in mature adipocytes exacerbates obesity. In this study, we constructed UCP1-positive adipocytes-specific Ctnnb1 knockout mice (UBKO) and observed increased "browning"of white adipose tissue (WAT) following cold exposure or CL-316,243 administration compared to controls. UBKO mice also displayed increased energy expenditure. Furthermore, 0-catenin (encoded by Ctnnb1) inhibited thermogenic genes expression in differentiated beige adipo-cytes and repressed Ucp1 expression at transcription level. Transcriptome anal-ysis revealed UBKO mice treated with CL-316,243 had enhanced mitochondrial function and downregulated immune-related genes in epididymal WAT. Improved glucose tolerance and insulin sensitivity were observed in 50 -week-old UBKO mice. Public datasets indicated that CTNNB1 expression was inversely correlated with several thermogenic genes expression in human adipose tissue/ adipocytes and positively correlated with BMI or waist-hip ratio (WHR). We pro-posed that intervention of 0-catenin in adipocytes could be an effective strategy to enhance energy expenditure and improve age-related metabolic performance.
The effects of obesity and metabolic abnormalities on severe COVID-19-related outcomes after vaccination: A population-based study
Fan, XD; Han, JM; Zhao, EF; Fang, JS; Wang, DW; Cheng, YP; Shi, YZ; Wang, Z; Yao, ZY; Lu, P; Liu, TB; Li, QH; Poulsen, KL; Yuan, ZS; Song, YF; Zhao, JJ
CELL METABOLISM 2023年 35卷4期 页码:585-
无关键词信息
Breakthrough SARS-CoV-2 infections of vaccinated individuals are being reported globally, resulting in an increased risk of hospitalization and death among such patients. Therefore, it is crucial to identify the modifi-able risk factors that may affect the protective efficacy of vaccine use against the development of severe COVID-19 and thus to initiate early medical interventions. Here, in population-based studies using the UK Biobank database and the 2021 National Health Interview Survey (NHIS), we analyzed 20,362 participants aged 50 years or older and 2,588 aged 18 years or older from both databases who tested positive for SARS-COV-2, of whom 33.1% and 67.7% received one or more doses of vaccine, respectively. In the UK Bio-bank, participants are followed from the vaccination date until October 18, 2021. We found that obesity and metabolic abnormalities (namely, hyperglycemia, hyperlipidemia, and hypertension) were modifiable factors for severe COVID-19 in vaccinated patients (all p < 0.05). When metabolic abnormalities were present, regard-less of obesity, the risk of severe COVID-19 was higher than that of metabolically normal individuals (all p < 0.05). Moreover, pharmacological interventions targeting such abnormalities (namely, antihypertensive [adjusted hazard ratio (aHR) 0.64, 95% CI 0.48-0.86; p = 0.003], glucose-lowering [aHR 0.55, 95% CI 0.36- 0.83; p = 0.004], and lipid-lowering treatments [aHR 0.50, 95% CI 0.37-0.68; p < 0.001]) were significantly associated with a reduced risk for this outcome. These results show that more proactive health management of patients with obesity and metabolic abnormalities is critical to reduce the incidence of severe COVID-19 after vaccination.
Oxysterol-Binding Protein: new insights into lipid transport functions and human diseases
Lin, YN; Ran, LY; Du, XM; Yang, HY; Wu, YJ
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2023年 1868卷9期 页码:-null
无关键词信息
Oxysterol-binding protein (OSBP) mediates lipid exchange between organelles at membrane contact sites, thereby regulating lipid dynamics and homeostasis. How OSBP's lipid transfer function impacts health and disease remain to be elucidated. In this review, we first summarize the structural characteristics and lipid transport functions of OSBP, and then focus on recent progresses linking OSBP with fatty liver disease, diabetes, lysosome-related diseases, cancer and viral infections, with the aim of discovering novel therapeutic strategies for common human diseases.
每页: 条
- <<
- <
- >
- >>