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Breast osteoblastoma and recurrence after resection: Demonstration by color Doppler ultrasound
Li, X;Xin, H;Yang, SF;Zhao, MQ;Wang, XM;Zhang, N
JOURNAL OF X-RAY SCIENCE AND TECHNOLOGY 2017年 25卷5期 页码:787-791
MALIGNANT-TRANSFORMATION; MRI
Osteoblastoma is a rare benign primary bone tumor, which occurs in any part of the skeleton. Extraskeletal osteoblastoma is rather rare. We presented an extremely rare case of extraskeletal osteoblastoma located in the breast. The tumor recurred 7 months later after resection and transformed to aggressive osteoblastoma. The histopathological features, ultrasonic manifestations and ultrasonic differential diagnoses of the primary and recurrent tumors were discussed. The recommended treatment of the tumor is surgical excision. Due to its tendency of recurrence and potential malignant transformation, adequate resection and careful follow up is essential.
Ultrasound elastographic evaluation of the median nerve in hemodialysis with carpal tunnel syndrome
Xin, H;Hu, HY;Liu, B;Liu, X;Li, X;Li, J
JOURNAL OF MEDICAL ULTRASONICS 2017年 44卷1期 页码:123-131
LONG-TERM HEMODIALYSIS; DIALYSIS-RELATED AMYLOIDOSIS; CONDUCTION-VELOCITY; DIAGNOSIS; SEVERITY
Purpose The aim of this study was to compare the elasticity of the median nerve (MN) between hemodialysis (HD) patients without carpal tunnel syndrome (CTS) and with CTS, and to evaluate the diagnostic usefulness of the elasticity of the MN in HD-CTS.;-;Materials and methods The MN in 22 HD patients without CTS and 49 HD-CTS patients was studied. The cross-sectional area (CSA) and the elasticity of the MN, which was measured as the subcutaneous fat/median nerve (SF/MN) strain ratio, were evaluated.;-;Results The mean SF/MN strain ratio in the groups that had received hemodialysis for 0-5, >5-10, and >10-15 years was 1.4 +/- 0.28, 1.7 +/- 0.18, and 2.0 +/- 0.67, respectively. The mean CSA of the MN in the three groups was 9.9 +/- 1.30, 11.6 +/- 1.61, and 13.4 +/- 2.14 mm(2), respectively. The presence of CTS was predicted by means of SF/MN strain ratio and CSA cutoff values of 1.8 and 11 mm(2), respectively. Both the SF/MN strain ratio and the CSA in the patients with CTS were higher than those in the patients without CTS (P < 0.05). The sensitivity and specificity of the SF/MN strain ratio and CSA of the MN were 75 and 92 % and 79.2 and 84 %, respectively.;-;Conclusion Sonoelastography helps to improve the diagnostic accuracy of the ultrasonographic assessment of CTS.
The feasibility of establishing classification system for ovarian function
Wang, W;Wang, YQ;Qin, YY;Dang, YJ;Xia, MD;Ma, Y;Mu, YL
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY 2016年 43卷5期 页码:631-637
ANTI-MULLERIAN HORMONE; IN-VITRO FERTILIZATION; REPRODUCTIVE TECHNOLOGY CYCLES; ANTRAL FOLLICLE COUNT; ANTIMULLERIAN HORMONE; MENSTRUAL-CYCLE; FSH/LH RATIO; SERUM-LEVELS; IVF PROGRAM; RESERVE
The occurrence, development, and decline of ovarian function are the foundation in women's whole life stages, which reflect the process beginning from embryo formation to the aging. Correct assessment of ovarian function is significant for evaluating the potential reproductive ability and predicting the age of menopause, as well as providing both individualized and proper treatment and preventive care based on physiological characteristics of women in different phases. Ovarian reserve (OR) is used to predict the potential fertility of women by evaluating the follicles and the quantity and quality of eggs. Currently, there are multiple indexes used to evaluate ovarian reserve, including anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH), estradiol (E2), inhibin B, antral follicle count (AFC), etc. Although some scholars combine multiple indexes to evaluate the ovarian function, these indexes are far less accurate, detailed, and comprehensive. To find an ideal method for evaluation of ovarian reserve is the hotspot in research of reproductive endocrine. The present authors, for the first time, put forward a classification system of ovarian reserve function after summarizing numerous cases. It can both accurately and effectively evaluate the ovarian function quantitatively. It is of great help in making clinical decisions and of great significance in future development.
Sonographic classification of draining pathways of obstructed hepatic veins in Budd-Chiari syndrome
Gai, YH;Cai, SF;Guo, WB;Zhang, CQ;Liang, B;Jia, T;Zhang, GQ
JOURNAL OF CLINICAL ULTRASOUND 2014年 42卷3期 页码:134-142
ASYMPTOMATIC MEMBRANOUS OBSTRUCTION; INFERIOR VENA-CAVA; COLLATERAL PATHWAYS
Purpose;-;To describe and propose a sonographic classification of the blood-draining pathways of obstructed hepatic veins in Budd-Chiari syndrome.;-;Methods;-;This retrospective study included 206 patients with hepatic vein obstructions who underwent sonographic examination. We evaluated the afflicted hepatic veins, as well as the course, orifice, blood flow direction of draining veins, and communicating branches.;-;Results were classified and compared with digital subtraction angiography and computed tomography angiography.;-;Results;-;Of 618 hepatic veins in 206 patients, 542 were obstructed. The blood-draining pathways were classified as hepatic vein-accessory hepatic vein (131/206), hepatic vein-hepatic vein/accessory hepatic+hepatic vein (49/206), and, less frequently, collateral pathways (26/206). Blood was drained from obstructed hepatic veins to the inferior vena cava, right atrium, para-umbilical veins, or hepatic subcapsular veins through communicating branches of various number and diameters. Doppler signals were obtained from the draining veins.;-;Conclusions;-;Sonography provides accurate information regarding the blood-draining pathways of obstructed hepatic veins in Budd-Chiari syndrome, which may be helpful for treatment and follow-up. (c) 2013 Wiley Periodicals, Inc. J Clin Ultrasound 42:134-142, 2014
The Effects of 17-beta Estradiol on Enhancing Proliferation of Human Bone Marrow Mesenchymal Stromal Cells In Vitro
Hong, L;Zhang, GQ;Sultana, H;Yu, Y;Wei, Z
STEM CELLS AND DEVELOPMENT 2011年 20卷5期 页码:925-931
ESTROGEN-RECEPTOR-ALPHA; ADULT STEM-CELLS; OSTEOGENIC DIFFERENTIATION; TELOMERASE ACTIVITY; SENESCENCE; EXPRESSION; ACTIVATION; THERAPY; PATHWAY; GENDER
Human bone marrow mesenchymal stromal cells (MSCs) with self-renewal and multiple differentiation potentials are considered a possible cell source for tissue engineering and regenerative medicine. However, the limited amount of MSCs in bone marrow and the loss of differentiation capacity following in vitro expansion restrict their practical application. Effective improvement of MSC proliferation is necessary for the clinical application of MSC-based tissue engineering. The effects of estrogen supplements on proliferation and characterizations of human MSCs were investigated at the present study. Supplements of 17-beta estradiol (E2) significantly increase the proliferation of human MSCs in vitro. The dose range of E2 to significantly increase MSC proliferation differs in the gender of MSC donor. E2 supplementation in cell proliferation maintains characterizations of MSCs, including cell surface markers, and osteogenic and adipogenic differentiation capacities. These data indicate that estrogen treatment can play an important role in improving human MSCs' expansion in vitro, which will effectively facilitate MSCs' function in the practical application of tissue engineering and regeneration.
Steroid regulation of proliferation and osteogenic differentiation of bone marrow stromal cells: A gender difference
Hong, L;Sultana, H;Paulius, K;Zhang, GQ
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 2009年 114卷3-5期 页码:180-185
MESENCHYMAL STEM-CELLS; MORPHOGENETIC PROTEIN-7; SKELETAL-MUSCLE; IN-VITRO; SEX; OSTEOBLASTS; ESTROGENS; METABOLISM; EXPRESSION; ESTRADIOL
Bone marrow mesenchymal stem cells (MSCs) are considered a potential cell source for stem cell-based bone tissue engineering. However, noticeable limitations of insufficient supply and reduction of differentiation potential impact the feasibility of their clinical application. This study investigated the in vitro function of steroids and gender differences on the proliferation and differentiation of rat MSCs. Bone marrow MSCs of age-matched rats were exposed to proliferation and osteogenic differentiation media supplements with various concentrations of 17 beta-estradiol (E2) and dexamethasone. Cell proliferation was measured by MTS assay; osteogenic markers and steroid-associated growth factors and receptors were evaluated by ELISA and real-time PCR. The results revealed that supplements of E2 and dexamethasone increase MSC proliferation in a biphasic manner. The optimal dose and interaction of steroids required to improve MSC proliferation effectively varied depending on the gender of donors. Supplementation of E2 effectively improves osteogenic differentiation markers including ALP, osteocalcin and calcium levels for MSCs isolated from both male and female donors. The mRNA of TGF-beta 1 and BMP-7 are also up-regulated. However, effective doses to maximally improve osteogenic potentials and growth factors for MSCs are different between male and female donors. The relationship between steroid receptors, osteogenic markers and cytokines are also varied by genders. The outcomes of the present study strongly indicate that steroids potentially function as an effective modulator to improve the capacity of MSCs in bone regeneration. It provides crucial information for improving and optimizing MSCs for future clinical application of bone regeneration. (C) Published by Elsevier Ltd.
Long-term effect of stent placement in 115 patients with Budd-Chiari syndrome
Zhang, CQ;Fu, LN;Xu, L;Zhang, GQ;Jia, T;Liu, JY;Qin, CY;Zhu, JR
WORLD JOURNAL OF GASTROENTEROLOGY 2003年 9卷11期 页码:2587-2591
INFERIOR VENA-CAVA; PORTOSYSTEMIC SHUNT; LIVER-TRANSPLANTATION; HEPATIC VEIN; OUTFLOW OBSTRUCTION; CURRENT MANAGEMENT; EXPERIENCE; ANGIOPLASTY; TIPS
AIM: To report the long-term effect of stent placement in 115 patients with Budd-Chiari syndrome (BCS).;-;METHODS: One hundred and fifteen patients with BCS were treated by percutaneous stent placement. One hundred and two patients had IVC stent placement, 30 patients had HV stent placement, 17 of them underwent both IVC stent and HV stent. All the procedures were performed with guidance of ultrasound.;-;RESULTS: The successful rates in placing IVC stent and HV stent were 94 % (96/102) and 87 % (26/30), respectively. Ninety-seven patients with 112 stents (90 IVC stents, 22 HV stents) were followed up. 96.7 %(87/90) IVC stents and 90.9 %(20/22) HV stents remained patent during follow up periods (mean 49 months, 45 months, respectively). Five of 112 stents in the 97 patients developed occlusion. Absence of anticoagulants after the procedure and types of obstruction (segmental and occlusive) before the procedure were related to a higher incidence of stent occlusion.;-;CONCLUSION: Patients with BCS caused by short length obstruction can be treated by IVC stent placement, HV stent placement or both IVC and HV stent placement depending on the sites of obstruction. The long-term effect is satisfactory. Anticoagulants are strongly recommended after the procedure especially for BCS patients caused by segmental occlusion.
Is Lung Ultrasound Useful for Diagnosing Pneumonia in Children?: A Meta-Analysis and Systematic Review
Xin, H;Li, J;Hu, HY
ULTRASOUND QUARTERLY 2018年 34卷1期 页码:3-10
COMMUNITY-ACQUIRED PNEUMONIA; CHEST RADIOGRAPHY; ULTRASONOGRAPHY; ADULTS; SIGN; TOOL
Background Childhood mortality due to pneumonia is high. Chest radiography is the primary imaging modality used for the evaluation of pneumonia in children. Lung ultrasonography (LUS) is a newer, alternative diagnostic method that has been gaining popularity in recent years. We conducted a meta-analysis to summarize the diagnostic usefulness of LUS for childhood pneumonia.;-;Methods All studies included in this meta-analysis were retrieved from PubMed, Elsevier's Science Direct, and Springer, and by manual searches including the use of reference lists, through March 31, 2017. Two researchers independently screened the literature, extracted the data, and evaluated risks of bias in accordance with the inclusion and exclusion criteria. For the meta-analysis, we calculated the pooled sensitivity and specificity, pooled positive likelihood ratio, negative likelihood ratio, and the diagnostic odds ratio. Summary receiver operating characteristic curve was used to assess the overall performance of LUS.;-;Results Our search identified 1038 articles, and we selected 51 of these for detailed review. Eight studies containing 1013 patients met all the inclusion criteria and were included in the final meta-analysis. The pooled sensitivity and specificity for the diagnosis of pneumonia using LUS were 93.0% (95% confidence interval, 88.0%-96.0%) and 96.0% (95% confidence interval, 92.0%-98.0%), respectively. The pooled positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 25.8 (11.0, 60.4), 0.07 (0.05, 0.12), and 344 (104, 1140), respectively. In addition, the summary receiver operating characteristic area under the curve was calculated to be 0.98 (0.97, 0.99). A Fagan plot analysis demonstrated that when pretest probabilities were 25%, 50%, and 75%, the positive posttest probabilities were 90%, 96%, and 99%, respectively, and the negative posttest probabilities were 2%, 7%, and 18%, respectively. Four clinical signs were most frequently observed using LUS in the screening of children with pneumonia: pulmonary consolidation, positive air bronchogram, abnormal pleural line, and pleural effusion.;-;Conclusions Current evidence supports LUS as a useful imaging alternative for the diagnosis of childhood pneumonia. That it is easily carried out, readily available, relatively inexpensive, and free from the hazards of radiation make it an attractive alternative to chest radiography and physical examination for the diagnosis and the follow-up of pneumonia in children.
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