在结果中搜索
成果类型 (Type)
收录类型 (Indexed By)
- 已选条件:
Association between birth weight and diabetes: Role of body mass index and lifestyle in later life
Hu, CY; Mu, YM; Wan, Q; Qin, YF; Hu, RY; Shi, LX; Su, Q; Yu, XF; Yan, L; Qin, GJ; Tang, XL; Chen, G; Gao, ZN; Wang, GX; Shen, FX; Luo, ZJ; Chen, L; Huo, YN; Li, Q; Ye, Z; Zhang, YF; Liu, C; Wang, YM; Wu, SL; Yang, T; Deng, HC; Chen, LL; Zhao, JJ; Lu, JL; Lin, L; Li, M; Du, R; Xu, M; Xu, Y; Wang, TG; Zhao, ZY; Chen, YH; Li, DH; Bi, YF; Wang, WQ; Ning, G
JOURNAL OF DIABETES 2020年 12卷1期 页码:10-20
THRIFTY PHENOTYPE; RISK-EVALUATION; MELLITUS; INDIVIDUALS; HEALTH; ADULTS; FETAL; HYPOTHESIS; GENOTYPE; EXPOSURE
Background This study investigated the association between birth weight and diabetes in a Chinese population, and the effects of body mass index (BMI) and lifestyle factors in later life on this association. Methods Data from 49 118 participants aged >= 40 years with recalled birth weight from the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) study, a nationwide population-based cohort, were used. Diabetes diagnosis was based on oral glucose tolerance tests and HbA1c measurements. Logistic regression models were used to evaluate the association of birth weight and risk of diabetes in later life. Results Increased risk of diabetes was associated with lower or higher birth weight. Compared with individuals with a birth weight of 2500 to 3499 g, the odds ratios (ORs) and 95% confidence intervals (CIs) of diabetes for individuals with a birth weight of <2500, between 3500 and 3999, and >= 4000 g were 1.28 (1.11-1.47), 1.11 (1.04-1.19), and 1.20 (1.07-1.34), respectively. Significant associations were prominent in participants with a current BMI >= 24 kg/m(2), but not detected in those with a normal BMI (OR 1.20 [95% CI 0.96-1.49], 1.11 [95% CI 0.98-1.25], and 1.10 [95% CI 0.89-1.37], respectively). Moreover, there was no increased risk of diabetes in individuals with a low birth weight but with healthy dietary habits (OR 0.94; 95% CI 0.68-1.29) or ideal physical activity (OR 1.41; 95% CI 0.97-2.04). Conclusions A U-shaped association was observed between birth weight and the risk of diabetes. Healthy lifestyles (healthy dietary habits or ideal physical activity) may eliminate the negative effects of low birth weight in the development of diabetes, but not the effect of high birth weight.
Hybrid versus in vitro fenestration for preserving the left subclavian artery in patients undergoing thoracic endovascular aortic repair with unfavorable proximal landing zone
Wang, MH; Dong, DN; Yuan, H; Wang, M; Wu, XJ; Zhang, SY; Zhong, ZY; Jin, X; Zhang, JY
VASCULAR 2020年 28卷1期 页码:42-47 影响因子:0.612
STENT GRAFTS; DISSECTION; MANAGEMENT; STRATEGY
Purpose To compare hybrid and in vitro fenestration procedures for preserving the left subclavian artery in thoracic endovascular aortic repair (TEVAR) with unfavorable proximal landing zone. Methods Retrospective comparison of data from 49 consecutive patients who underwent left subclavian artery revascularization during TEVAR by either hybrid or fenestration approaches from January 2015 to March 2018. Procedural duration, and 30-day rates of procedural success, mortality and complications (endoleaks, cerebral infarction, spinal cord ischemia, left arm ischemic symptoms, and delirium) were compared. Results For hybrid procedure (n = 32) vs. fenestration (n = 17) groups, which were age and gender matched: procedural success rate was 100%, with significantly longer procedural duration (248.4 +/- 40.9 vs. 60.6 +/- 16.8 min; t = -22.653, P = 0.000) and similar 30-day complication rate (18.8% vs. 11.8%; chi(2) = 0.397, P = 0.529). At 12.7 +/- 9.3 months' follow-up, there were no cases of death, spinal cord ischemia, or other complications in either group. Conclusions In this retrospective, single-center comparison, both hybrid and in vitro fenestration approaches for reconstructing the left subclavian artery in TEVAR with unfavorable proximal landing zone appeared safe and effective, with shorter procedural duration for fenestration. Larger studies with longer term follow-up are warranted.
Observational study evaluating the effectiveness of physician-targeted education for improving glycemic management of patients with type 2 diabetes (BEYOND II)
Weng, JP; Zhao, JJ; Zhou, ZG; Guo, XH; Zou, DJ; Ji, QH; Tong, NW; Li, QF; Zhu, J; Li, Q; Qin, GJ; Feng, P; Yang, LY; Gao, ZN; Chen, LL; Li, H; Li, YM; Zeng, LY; Zhu, DL; Lu, JM; Luo, TH; Cui, N
JOURNAL OF DIABETES 2020年 12卷1期 页码:66-76
QUALITY IMPROVEMENT STRATEGIES; BASAL INSULIN; CARE; ACHIEVEMENT; ASSOCIATION; OUTPATIENT; DRUGS; CHINA
Background Because there has been no quality improvement initiatives targeting patients with type 2 diabetes (T2D) receiving basal insulin therapy, this study evaluated the effectiveness of physician-targeted education for optimizing glycemic management in these patients in China. Methods This multicenter open-label observational study conducted across China had a baseline sample survey, followed by a 6-month education program, and ended with a post-education sample survey. Education based on T2D treatment guidelines was given at Months 1 and 3, and was reinforced by self-audit every month. Each hospital enrolled 100 patients with T2D receiving basal insulin at both the baseline and post-education survey. The primary outcome was the proportion of hospitals meeting individual improvement goals. The goal setting was based on the proportion of patients achieving HbA1c Overall, the individual improvement goal was achieved by 35 centers (49%). Hospitals with poor glycemic management at the baseline survey had higher possibility to improve at post-education survey. Two large sample surveys at baseline and post-education showed improved glucose management among these hospitals. A higher proportion of patients achieved HbA1c <7.0% in the post-education survey (27.2% vs 36.5%; P < 0.001) with reduced HbA1c levels (8.10% vs 7.72%; P < 0.001). Questionnaires from 723 physicians showed that confidence and practice of basal insulin use were significantly improved. Conclusions Physician-targeted education improved glycemic management of patients with T2D in 71 hospitals in China, and was more effective at hospitals with poor glycemic management at the baseline survey.
Retrospective analysis of 586 cases of placenta previa and accreta
Peng, W; Shen, L; Wang, S; Wang, HM
JOURNAL OF OBSTETRICS AND GYNAECOLOGY 2020年 40卷5期 页码:609-613
PROPHYLACTIC BALLOON OCCLUSION; ABNORMALLY INVASIVE PLACENTA; CESAREAN HYSTERECTOMY; ILIAC ARTERIES; MRI; MANAGEMENT; DELIVERY; SUTURE
In this study, we conducted a retrospective investigation of all cases of placenta previa and accreta that were treated at a tertiary-level hospital to assess the effectiveness of balloon catheterisation at different levels. We evaluated the surgical and neonatal outcomes of 586 cases of placenta previa and accreta that were treated at our facility. This is the largest study of its kind. Depending on the severity and position of accreta, patients underwent balloon catheter placement in the aorta (n = 252) or common iliac artery (n = 38) before delivery by caesarean section. Data were collected regarding the duration of the surgery, number of cases (percentage) of balloon occlusion, and annual rate of hysterectomy. The blood loss (2207.89 +/- 2044.95 ml) and transfusion volume (7.42 +/- 7.872 U) in the common iliac occlusion group was greater than those in the aortic occlusion group (1967.66 +/- 1466.64 ml and 6.54 +/- 5.67 U, respectively); however, this difference did not reach statistical significance (p > .05). With the increase in the number of procedures performed over the years of study, the surgeons' skills improved significantly. The choice of balloon catheterisation must be made with careful consideration. Our results highlight the significance of suture skill and the experience level of surgeons.IMPACT STATEMENT What is already known on this subject: The optimal method for the management of placenta accreta remains debateable. Prophylactic balloon catheters placed within arteries to control intraoperative bleeding play an important role in the management of patients with placenta accreta. What the results of this study add: The common iliac artery occlusion group tended to have a greater amount of blood loss and a higher requirement of transfusion than the aortic occlusion group; however, this difference was not statistically significant. We also analysed the difference in the complications across different periods of the study period and observed a clear improvement in the operative procedures over time.
Effects of Titanium Nano-Foveolae Surfaces on Human Gingival Fibroblasts
Zhang, YJ; Zhang, YL; Kong, TT; Ye, B; Li, XY; Ji, P; Sun, SJ
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 2020年 20卷2期 页码:673-679
GENE-EXPRESSION; TOPOGRAPHY; IMPLANTS; FABRICATION; INTEGRATION; MORPHOLOGY; ADHESION
A proper soft tissue seal between implants and gingiva is critical for success of dental implants. Implant surface modification is an important approach for achieving ideal host-implant integration. In this study, we used a new and simple oxidation method to generate a rough surface on implants at the nano scale, which oxidized titanium nano-foveolae (TiNF) surface. We further analyzed the surface topography and tested its effects on biological activities of human gingival fibroblasts. Atomic force microscopy (AFM) and scanning electron microscopy (SEM) examination demonstrated that TiNF disks displayed uniform rough surfaces, with average TiNF diameters of approximately 60 nm and 100 nm respectively. However the surfaces of smooth samples were highly irregular, and cell adhesion and proliferation rates on TiNF surfaces were significantly higher than those of the smooth surfaces. Extracellular matrix synthesis was also increased in the cells that interacted with oxidized TiNF surfaces. Altogether, these results suggest that the TiNF implant surfaces perform better for human gingival fibroblast biological activities compared to traditional smooth surfaces. Therefore, the TiNF implant surfaces may serve as ideal interface to facilitate implant-host integration.
Fenofibrate-induced hepatotoxicity: A case with a special feature that is different from those in the LiverTox database
Ma, SZ; Liu, SD; Wang, Q; Chen, LJ; Yang, P; Sun, HH
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS 2020年 45卷1期 页码:204-207
TRANSAMINASE GENE-EXPRESSION; CARDIOVASCULAR-DISEASE; INJURY; INTERVENTION; HEPATITIS; DYSLIPIDEMIA; POPULATION; FAILURE
What is known and objective We report a special case of fenofibrate-induced acute severe DILI with sudden onset and rapid recovery, which is different from those in the LiverTox database. Case summary description The acute severe DILI occurred within only 4 days after fenofibrate initial treatment for hypertriglyceridemia. Liver enzyme levels eventually declined to normal within two weeks after the discontinuation of fenofibrate. What is new and Conclusion Early detection of elevated hepatic enzymes after fenofibrate initial treatment helps physicians to avoid delayed diagnosis and subsequent treatment.
N-acetylglucosaminyltransferase I promotes glioma cell proliferation and migration through increasing the stability of the glucose transporter GLUT1
Li, YN; Liu, YC; Zhu, HD; Chen, XN; Tian, M; Wei, YY; Gong, Y; Jiang, JH
FEBS LETTERS 2020年 594卷2期 页码:358-366
EPIDERMAL-GROWTH-FACTOR; FACTOR RECEPTOR; GLYCOSYLATION; OLIGOSACCHARIDES; ACTIVATION; EXPRESSION; INVASION; COMPLEX
Abnormal alteration of N-glycosylation structure contributes to glioma progression. N-acetylglucosaminyltransferase I (MGAT1) plays an essential role in the conversion of processed high-mannose cores into complex or hybrid N-linked oligosaccharide structures. The function of MGAT1 in glioma development remains largely unknown. Here, we found that the expression of MGAT1 is higher in glioblastoma compared to normal brain tissues. Inhibition of EGFR signalling pathway or serum starvation reduces MGAT1 expression. Knockdown of MGAT1 inhibits glioma cell proliferation and migration. Furthermore, MGAT1 promotes complex N-glycosylation of glucose transporter 1 (Glut1) and increases Glut1 protein levels. In summary, our findings indicate that MGAT1 is highly expressed in glioblastoma and promotes glioma cells at least partly through upregulation of Glut1 protein.
RKI-1447 suppresses colorectal carcinoma cell growth via disrupting cellular bioenergetics and mitochondrial dynamics
Li, LY; Chen, Q; Yu, YJ; Chen, H; Lu, MD; Huang, YP; Li, PH; Chang, H
JOURNAL OF CELLULAR PHYSIOLOGY 2020年 235卷1期 页码:254-266
KINASE ROK-ALPHA; CITRON KINASE; CANCER-CELLS; APOPTOSIS; RHO; PROTEIN; ACTIVATION; INVASION; REORGANIZATION; METASTASIS
Accumulated evidence suggested the importance of the Rho/Rho-kinase (ROCK) signaling pathway in cancer proliferation and invasion. However, its role in colorectal carcinoma (CRC) is not well understood. This study evaluated the effect of ROCK signaling pathway on CRC behavior on the basis of a novel Rho/ROCK inhibitor RKI-1447. Here, we found RKI-1447 could drastically suppress HCT-8 and HCT-116 cell growth and promoted apoptosis. Our in vitro data indicated suppressed cytoskeletal dynamics induced by RKI-1447 inhibition on mitochondrial respiration, which was evidenced by basal and maximal respiration rates, and ATP production. Simultaneously, cellular basal and maximal glycolytic rates, and glycolytic capacity were also reduced in response to RKI-1447. Moreover, RKI-1447 caused excessive reactive oxygen species generation and membrane depolarization as well as activated ER-stress. We also demonstrated CHOP is essential for RKI-1447 induced cell apoptosis. Finally, we proved inhibition of ROCK by RKI-1447 could effectively inhibit CRC growth in vivo. Taken together, this study demonstrated that inhibition of ROCK signaling pathway by RKI-1447 could suppress CRC via cytoskeleton associated mitochondrial dysfunction and cellular bioenergetics disruption. Our data suggest RKI-1447 may be an attractive antitumor drug candidate for the treatment of CRC.
Comparison of long fusion terminating at L5 versus the sacrum in treating adult spinal deformity: a meta-analysis
Jia, F; Wang, GD; Liu, XY; Li, T; Sun, JM
EUROPEAN SPINE JOURNAL 2020年 29卷1期 页码:24-35
MINIMUM 5-YEAR ANALYSIS; RISK-FACTORS; SACROPELVIC FIXATION; JUNCTIONAL KYPHOSIS; SURGICAL OUTCOMES; ILIAC SCREWS; SCOLIOSIS; INSTRUMENTATION; SEGMENT; L5-S1
Purpose Choosing an optimal distal fusion level for adult spinal deformity (ASD) is still controversial. To compare the radiographic and clinical outcomes of distal fusion to L5 versus the sacrum in ASD, we conducted a meta-analysis. Methods Relevant studies on long fusion terminating at L5 or the sacrum in ASD were retrieved from the PubMed, Embase, Cochrane, and Google Scholar databases. Then, studies were manually selected for inclusion based on predefined criteria. The meta-analysis was performed by RevMan 5.3. Results Eleven retrospective studies with 1211 patients were included in meta-analysis. No significant difference was found in overall complication rate (95% CI 0.60 to 1.30) and revision rate (95% CI 0.59 to 1.99) between fusion to L5 group (L group) and fusion to the sacrum group (S group). Significant lower rate of pseudarthrosis and implant-related complications (95% CI 0.29 to 0.64) as well as proximal adjacent segment disease (95% CI 0.35 to 0.92) was found in L group. Patients in S group obtained a better correction of lumbar lordosis (95% CI - 7.85 to - 0.38) and less loss of sagittal balance (95% CI - 1.80 to - 0.50). Conclusion Our meta-analysis suggested that long fusion terminating at L5 or the sacrum was similar in scoliosis correction, overall complication rate, revision rate, and improvement in pain and disability. However, fusion to L5 had advantages in lower rate of pseudarthrosis, implant-related complications, and proximal adjacent segment disease, while fusion to the sacrum had advantages in the restoration of lumbar lordosis, maintenance of sagittal balance, and absence of distal adjacent segment disease. [GRAPHICS] .
Correlation between the apex of lumbar lordosis and pelvic incidence in asymptomatic adult
Pan, CY; Wang, GD; Sun, JM
EUROPEAN SPINE JOURNAL 2020年 29卷3期 页码:420-427
SAGITTAL PLANE CORRECTION; QUALITY-OF-LIFE; RADIOGRAPHIC PARAMETERS; ALIGNMENT; SPINE; BALANCE; DEFORMITY; VALUES; FUSION; IMPACT
Purpose The objective of this study was to test the correlation between the apex of lumbar lordosis (LLA) and pelvic incidence (PI) in asymptomatic adults, and to establish predictive formulae based on the PI to obtain the reference values of lumbar sagittal parameters. Methods A cohort of 183 asymptomatic volunteers older than 18 years was enrolled in this study between April 2017 and May 2019. A full-spine, standing X-ray was taken for each subject. The following parameters in the sagittal plane were measured: the LLA, the distance between the plumb line of the lumbar apex (LAPL) and gravity plumb line, lumbar lordosis (LL), the upper arc of lumbar lordosis (LLUA), the lower arc of lumbar lordosis (LLLA) and the PI. The correlations between lumbar parameters and PI were analysed, and simple linear regressions were simultaneously constructed. The statistical significance level was P < 0.05. Results The PI was statistically correlated with the LLA (r(s) = - 0.595, P < 0.001), LAPL (r(s) = 0.503, P < 0.001), LL (r(s) = 0.605, P < 0.001), LLUA (r = 0.354, P < 0.001) and the LLLA (r = 0.658, P < 0.001). The corresponding regression formulae were as follows: LLA = - 0.042*PI + 6.134 (R-2 = 0.306), LAPL = 0.448*PI + 26.570 (R-2 = 0.279), LL = 0.888*PI - 2.667 (R-2 = 0.370), LLUA = 0.272*PI - 2.297 (R-2 = 0.126) and LLLA = 0.607*PI + 0.177 (R-2 = 0.433). Conclusion The PI has strong correlations with the LLA, LAPL, LL, LLUA and LLLA, which demonstrates that the specific lumbar shape can be affected by the pelvic morphology. Moreover, predictive models for ideal lumbar sagittal parameters based on the PI have been developed, contributing to the design of precise and individualized preoperative plans. [GRAPHICS] .
每页: 条
- <<
- <
- >
- >>